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Front Biosci (Landmark Ed). 2016 Jun 1;21:1286-95.

Down-regulation and gene hypermethylation of the 14-3-3 gamma in uterine leiomyoma.

Author information

  • 1Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
  • 2Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
  • 3Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China, zjwzzxq@yeah.net.

Abstract

We demonstrated that the expression of 14-3-3 gamma was lower in uterine leiomyomas compared to the adjacent normal myometrium. Here, we show that 14-3-3 gamma promoter is methylated more in leiomyomas than myometrium. The level of 14-3-3 gamma protein in leiomyomas did not change in respect to age, size, location, or the type of leiomyoma. ER-alpha, ER-beta, and PR proteins were also higher in leiomyomas and the level of these proteins negatively correlated with the level of 14-3-3 gamma protein. These results suggest that the hypermethylation of the 14-3-3 gene promoter accounts for the decreased 14-3-3 gamma in leiomyomas and that such a low level of expression may be involved in the pathogenesis of leiomyomas.

PMID:
27100507
[PubMed - in process]
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