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Nat Chem Biol. 2016 Jun;12(6):396-8. doi: 10.1038/nchembio.2065. Epub 2016 Apr 18.

The Taf14 YEATS domain is a reader of histone crotonylation.

Author information

1
Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado, USA.
2
Department of Biochemistry &Biophysics, the University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
3
Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Abstract

The discovery of new histone modifications is unfolding at startling rates; however, the identification of effectors capable of interpreting these modifications has lagged behind. Here we report the YEATS domain as an effective reader of histone lysine crotonylation, an epigenetic signature associated with active transcription. We show that the Taf14 YEATS domain engages crotonyllysine via a unique π-π-π-stacking mechanism and that other YEATS domains have crotonyllysine-binding activity.

PMID:
27089029
PMCID:
PMC4871749
DOI:
10.1038/nchembio.2065
[Indexed for MEDLINE]
Free PMC Article

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