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Infect Genet Evol. 2016 Jul;41:227-232. doi: 10.1016/j.meegid.2016.04.004. Epub 2016 Apr 13.

Sequencing and molecular modeling identifies candidate members of Caliciviridae family in bats.

Author information

1
Virological Research Group, János Szentágothai Research Center, University of Pécs, Pécs, Hungary; Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary.
2
Department of Applied Genomics, Agricultural Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, Martonvásár, Hungary.
3
Department of Zoology, Hungarian Natural History Museum, Budapest, Hungary; Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary.
4
Aggtelek National Park Directorate, Jósvafő, Hungary.
5
Department of Zoology, Eszterházy Károly College, Eger, Hungary.
6
Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary.
7
Dipartimento di Medicina Veterinaria, Universitá Aldo Moro di Bari, Valenzano, Italy.
8
Virological Research Group, János Szentágothai Research Center, University of Pécs, Pécs, Hungary; Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary. Electronic address: jakabf@gamma.ttk.pte.hu.

Abstract

Emerging viral diseases represent an ongoing challenge for globalized world and bats constitute an immense, partially explored, reservoir of potentially zoonotic viruses. Caliciviruses are important human and animal pathogens and, as observed for human noroviruses, they may impact on human health on a global scale. By screening fecal samples of bats in Hungary, calicivirus RNA was identified in the samples of Myotis daubentonii and Eptesicus serotinus bats. In order to characterize more in detail the bat caliciviruses, large portions of the genome sequence of the viruses were determined. Phylogenetic analyses and molecular modeling identified firmly the two viruses as candidate members within the Caliciviridae family, with one calicivirus strain resembling members of the Sapovirus genus and the other bat calicivirus being more related to porcine caliciviruses of the proposed genus Valovirus. This data serves the effort for detecting reservoir hosts for potential emerging viruses and recognize important evolutionary relationships.

KEYWORDS:

Bat; Calicivirus; Daubenton's bat; Europe; Hungary; Protein modeling; Serotine bat; Virus

PMID:
27085289
DOI:
10.1016/j.meegid.2016.04.004
[Indexed for MEDLINE]

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