Format

Send to

Choose Destination
Cell Stem Cell. 2016 Apr 7;18(4):427-8. doi: 10.1016/j.stem.2016.03.019.

EnaBILEing Growth in the Fetal Liver.

Author information

1
Genetics and Gastroenterology Divisions, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Gastrointestinal Cancer Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: wgoessling@partners.org.
2
Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. Electronic address: tnorth@bidmc.harvard.edu.

Abstract

Blood stem cells develop at successive sites in the vertebrate embryo, but the functional explanation for this behavior is unknown. Sigurdsson et al. (2016) provide justification for transient fetal liver residence, where select bile acid composition, derived from mother and embryo, provides a protective environment, enabling rapid stem cell expansion.

PMID:
27058931
DOI:
10.1016/j.stem.2016.03.019
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center