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Ann N Y Acad Sci. 2016 Apr;1370(1):97-108. doi: 10.1111/nyas.13030. Epub 2016 Mar 25.

Endothelial-to-hematopoietic transition: Notch-ing vessels into blood.

Author information

1
Department of Stem Cell and Regenerative Biology, Harvard University, Boston, Massachusetts.
2
Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
3
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
4
Harvard Stem Cell Institute, Cambridge, Massachusetts.
5
Division of Hematology, University Hospital Basel, Basel, Switzerland.

Abstract

During development, hematopoietic stem cells (HSCs) are formed in a temporally and spatially restricted manner, arising from specialized endothelial cells (ECs) in the ventral wall of the dorsal aorta within the evolutionary conserved aorta-gonad-mesonephros region. Our understanding of the processes regulating the birth of HSCs from ECs has been recently advanced by comprehensive molecular analyses of developing murine hematopoietic cell populations complemented by studies in the zebrafish model, with the latter offering unique advantages for genetic studies and direct in vivo visualization of HSC emergence. Here, we provide a concise review of the current knowledge and recent advances regarding the cellular origin and molecular regulation of HSC development, with particular focus on the process of endothelial-to-hematopoietic transition and its primary regulator, the Notch signaling pathway.

KEYWORDS:

GPR56; Notch; endothelial-to-hematopoietic transition; hematopoiesis; hematopoietic stem cells

PMID:
27015586
DOI:
10.1111/nyas.13030
[Indexed for MEDLINE]

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