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Cell. 2016 Mar 24;165(1):13-15. doi: 10.1016/j.cell.2016.03.005.

The Molecular Harbingers of Early Mammalian Embryo Patterning.

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1
Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
2
Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: belmonte@salk.edu.

Abstract

Random or not, the mechanisms at play during the first cell-fate determination in mammalian embryos have been debated for years. Studies by Goolam et al. and White et al. shed new light on the molecular mechanisms underlying the intrinsic biases that lead to non-random lineage segregation in early mammalian development.

PMID:
27015301
DOI:
10.1016/j.cell.2016.03.005
[Indexed for MEDLINE]
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