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J Clin Pharm Ther. 2002 Apr;27(2):139-42.

Leaching of diethylhexyl phthalate from polyvinyl chloride bags into intravenous etoposide solution.

Author information

1
Pharmacie Brabois Adultes - Centre Hospitalier Universitaire de Nancy, Allée du Morvan, Vandoeuvre-les-Nancy, France. bdemore@club-internet.fr

Abstract

OBJECTIVE:

To compare the release of diethylhexyl phthalate (DEHP) from polyvinyl chloride (PVC) bags from four different manufacturers into intravenous etoposide solutions.

METHOD:

Etoposide solutions, 0.4 mg/mL, containing the vehicle polysorbate 80 were prepared in 5% dextrose or 0.9% sodium chloride injection PVC bags and stored at room temperature for 24 h. DEHP content was analysed by high-performance liquid chromatography.

RESULTS:

Substantial amounts of DEHP (up to 20 microg/mL at room temperature) leached into the etoposide solutions. However, no significant differences were found in the amounts of DEHP leached into the etoposide infusion solutions prepared using either 5% dextrose or 0.9% sodium chloride injection and stored in the four different containers.

CONCLUSION:

To minimize patient exposure o DEHP, etoposide solutions should ideally be stored in a glass or polyolefin container.

PMID:
11975699
[Indexed for MEDLINE]

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