Format

Send to

Choose Destination
Kidney Int. 2016 Apr;89(4):740-2. doi: 10.1016/j.kint.2016.01.009.

Targeting the fatty acid transport protein CD36, a class B scavenger receptor, in the treatment of renal disease.

Author information

1
Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
2
Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: motoy@kuhp.kyoto-u.ac.jp.

Abstract

Augmentation of the CD36 pathway, which involves the uptake of several endogenous ligands including free fatty acids and oxidized low-density lipoprotein, contributes to the damage of proximal tubules and podocytes, whereas ablation of CD36 attenuates renal injury. Souza et al. demonstrate that 5A peptide can inhibit CD36 signaling, attenuate chronic kidney disease progression, and ameliorate inflammation and tubulointerstitial fibrosis by reducing the expression of inflammatory cytokines and chemokines, suggesting the therapeutic potential of 5A peptide against CD36-mediated renal injury.

PMID:
26994570
DOI:
10.1016/j.kint.2016.01.009
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center