Send to

Choose Destination
Bioessays. 2016 May;38(5):420-6. doi: 10.1002/bies.201500122. Epub 2016 Mar 15.

Histone chaperones FACT and Spt6 prevent histone variants from turning into histone deviants.

Author information

Institut de recherches cliniques de Montréal, Montréal, Québec, Canada.
Département de Médecine, Faculté de Médecine, Université de Montréal, Montréal, Québec, Canada.


Histone variants are specialized histones which replace their canonical counterparts in specific nucleosomes. Together with histone post-translational modifications and DNA methylation, they contribute to the epigenome. Histone variants are incorporated at specific locations by the concerted action of histone chaperones and ATP-dependent chromatin remodelers. Recent studies have shown that the histone chaperone FACT plays key roles in preventing pervasive incorporation of two histone variants: H2A.Z and CenH3/CENP-A. In addition, Spt6, another histone chaperone, was also shown to be important for appropriate H2A.Z localization. FACT and Spt6 are both associated with elongating RNA polymerase II. Based on these two examples, we propose that the establishment and maintenance of histone variant genomic distributions depend on a transcription-coupled epigenome editing (or surveillance) function of histone chaperones.


CENP-A; CenH3; Cse4; FACT; H2A.Z; Psh1; SWR-C; Spt16; Spt6; histone chaperone; histone variant; ubiquitin

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center