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J Agric Food Chem. 2016 Mar 9;64(9):1921-31. doi: 10.1021/acs.jafc.5b05610. Epub 2016 Feb 24.

Structural Characterization and Immunomodulatory Activity of a Novel Polysaccharide from Lepidium meyenii.

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College of Light Industry and Food Sciences, South China University of Technology , Guangzhou, Guangdong 510640, China.
Guangdong Provincial Key Laboratory of Green Agricultural Products Processing, Guangzhou, Guangdong 510640, China.


A novel polysaccharide named as MC-1 was isolated from the roots of Lepidium meyenii using a water extraction method. Structural characterization revealed that MC-1 had an average molecular weight of 11.3 kDa and consisted of arabinose (26.21%), mannose (11.81%), glucose (53.66%), and galactose (8.32%). The main linkage types of MC-1 were proven to be (1 → 5)-α-L-Ara, (1 → 3)-α-L-Man, (1 → 2,6)-α-L-Man, (1 → )-α-D-Glc, (1 → 4)-α-D-Glc, (1 → 6)-α-D-Glc and (1 → 6)-β-D-Gal by methylation analysis, periodate oxidation-Smith degradation and NMR analysis. The immunostimulating assay indicated that MC-1 could significantly enhance the pinocytic and phagocytic capacity and promote the NO, TNF-α, and IL-6 secretion of RAW 264.7 cells, involving toll-like receptor 2, complement receptor 3, and mannose receptor mainly. These results suggested the potential utilization of MC-1 as an attractive functional food supplement candidate for hypoimmunity population.


Lepidium meyenii; immunomodulatory activity; polysaccharide; structural characterization

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