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Trends Microbiol. 2016 Apr;24(4):239-241. doi: 10.1016/j.tim.2016.01.010. Epub 2016 Feb 12.

A Deadly Path: Bacterial Spread During Bubonic Plague.

Author information

1
Department of Microbiology and Immunology, University of North Carolina, 125 Mason Farm Road, CB# 7290, University of North Carolina, Chapel Hill, NC 27599, USA.
2
Department of Microbiology and Immunology, University of North Carolina, 125 Mason Farm Road, CB# 7290, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina, 120 Mason Farm Road, Genetic Medicine Building, CB# 7264, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: vlmiller@med.unc.edu.

Abstract

Yersinia pestis causes bubonic plague, a fulminant disease where host immune responses are abrogated. Recently developed in vivo models of plague have resulted in new ideas regarding bacterial spread in the body. Deciphering bacterial spread is key to understanding Y. pestis and the immune responses it encounters during infection.

KEYWORDS:

Yersinia pestis; bubonic plague; dissemination

PMID:
26875618
PMCID:
PMC4808365
DOI:
10.1016/j.tim.2016.01.010
[Indexed for MEDLINE]
Free PMC Article

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