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AJNR Am J Neuroradiol. 2016 Jun;37(6):1178-84. doi: 10.3174/ajnr.A4687. Epub 2016 Feb 11.

Relationship between M100 Auditory Evoked Response and Auditory Radiation Microstructure in 16p11.2 Deletion and Duplication Carriers.

Author information

1
From the Department of Radiology (J.I.B., D.C., L.B., E.K., T.P.L.R.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania Department of Radiology (J.I.B., T.P.L.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania bermanj@email.chop.edu.
2
From the Department of Radiology (J.I.B., D.C., L.B., E.K., T.P.L.R.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
3
Departments of Radiology (P.M.).
4
Department of Psychology (R.B.), Harvard University, Cambridge, Massachusetts.
5
Departments of Pediatrics and Medicine (S.N., W.K.C.), Columbia University Medical Center, New York, New York.
6
Neurology (E.H.S.), University of California, San Francisco School of Medicine, San Francisco, California.
7
From the Department of Radiology (J.I.B., D.C., L.B., E.K., T.P.L.R.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania Department of Radiology (J.I.B., T.P.L.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Abstract

BACKGROUND AND PURPOSE:

Deletion and duplication of chromosome 16p11.2 (BP4-BP5) have been associated with developmental disorders such as autism spectrum disorders, and deletion subjects exhibit a large (20-ms) delay of the auditory evoked cortical response as measured by magnetoencephalography (M100 latency). The purpose of this study was to use a multimodal approach to test whether changes in white matter microstructure are associated with delayed M100 latency.

MATERIALS AND METHODS:

Thirty pediatric deletion carriers, 9 duplication carriers, and 39 control children were studied with both magnetoencephalography and diffusion MR imaging. The M100 latency and auditory system DTI measures were compared between groups and tested for correlation.

RESULTS:

In controls, white matter diffusivity significantly correlated with the speed of the M100 response. However, the relationship between structure and function appeared uncoupled in 16p11.2 copy number variation carriers. The alterations to auditory system white matter microstructure in the 16p11.2 deletion only partially accounted for the 20-ms M100 delay. Although both duplication and deletion groups exhibit abnormal white matter microstructure, only the deletion group has delayed M100 latency.

CONCLUSIONS:

These results indicate that gene dosage impacts factors other than white matter microstructure, which modulate conduction velocity.

PMID:
26869473
PMCID:
PMC4907815
DOI:
10.3174/ajnr.A4687
[Indexed for MEDLINE]
Free PMC Article

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