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Clin Chim Acta. 2016 Apr 1;455:154-60. doi: 10.1016/j.cca.2016.01.034. Epub 2016 Feb 4.

Parathyroid hormone, cardiovascular and all-cause mortality: A meta-analysis.

Author information

1
Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China. Electronic address: dryangb@aliyun.com.
2
Department of Cardiology, Beijing Chaoyang Hospital affiliated to Capital Medical University, Beijing 100020, China. Electronic address: liuchanglinbeij@sina.com.
3
Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China.

Abstract

BACKGROUND:

Inconsistent findings have reported on parathyroid hormone (PTH) concentration and cardiovascular or all-cause mortality.

OBJECTIVE:

To investigate whether elevated PTH concentration was an independent predictor for cardiovascular or all-cause mortality in the general population by conducting a meta-analysis based on prospective studies.

METHOD:

We searched Cochrane Library, Pubmed, and Embase databases up to June 2015. Only prospective studies evaluating serum PTH concentration and cardiovascular or all-cause mortality were included. Pooled adjust risk ratio (RR) and corresponding 95% confidence intervals (CI) were calculated for the highest vs. lowest PTH concentration.

RESULTS:

Ten studies with 31,616 subjects were identified and analyzed. Compared the highest to the lowest PTH concentration, elevated serum PTH concentration increased the risk of all-cause mortality (RR 1.19; 95% CI 1.08-1.30) but not for cardiovascular mortality (RR 1.26; 95% CI 0.96-1.66). Subgroup analyses indicated that cardiovascular mortality risk appeared to be more pronounced among men (RR 1.68; 95% CI 1.05-2.67).

CONCLUSIONS:

Elevated PTH concentration is an independent predictor of all-cause mortality. Elevated serum PTH concentration appears to increase risk of cardiovascular mortality among men.

KEYWORDS:

All-cause mortality; Cardiovascular mortality; Meta-analysis; Parathyroid hormone

PMID:
26835752
DOI:
10.1016/j.cca.2016.01.034
[Indexed for MEDLINE]

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