Format

Send to

Choose Destination
Cell Res. 2016 Feb;26(2):147-8. doi: 10.1038/cr.2016.9. Epub 2016 Jan 22.

The XEN of reprogramming.

Author information

1
Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

Reprogramming to pluripotency has thus far required complex procedures involving nuclear transfer, cell fusion or genetic manipulation. Two recent papers from Hongkui Deng's group now show various cell types can be reprogrammed simply by chemicals through an extraembryonic endoderm-like phase instead of the primitive streak-like mesendoderm induced by Yamanaka factors.

PMID:
26794872
PMCID:
PMC4746615
DOI:
10.1038/cr.2016.9
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center