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Chemosphere. 2016 Mar;147:389-95. doi: 10.1016/j.chemosphere.2015.12.113. Epub 2016 Jan 15.

Hydroxylated polychlorinated biphenyls in human sera from adolescents and their mothers living in two U.S. Midwestern communities.

Author information

1
Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, United States.
2
Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, United States; Department of Civil and Environmental Engineering, The University of Iowa, Iowa City, IA 52242, United States. Electronic address: keri-hornbuckle@uiowa.edu.
3
Department of Civil and Environmental Engineering, The University of Iowa, Iowa City, IA 52242, United States.
4
Department of Biostatistics, The University of Iowa, Iowa City, IA 52242, United States.
5
Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, United States; Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA 52242, United States. Electronic address: peter-thorne@uiowa.edu.

Abstract

Hydroxylated polychlorinated biphenyls (OH-PCBs) have been detected in human specimens and some are suspected as being more toxic than their parent compounds. We compared 58 OH-PCB congeners (in 51 chromatographic peaks) in serum samples from participants in the AESOP Study, a longitudinal cohort study of adolescents and their mothers living in urban and rural areas in the United States. We hypothesized that adolescents would have lower levels of OH-PCBs than their mothers and that serum concentration of OH-PCBs would be stable over a 3-year period. We found statistically significant differences in total OH-PCBs between age groups in both East Chicago (p = 0.001) and Columbus Junction (p < 0.001), with adolescents having lower concentrations than their mothers. We observed that lower-chlorinated OH-PCBs were rarely detected, suggesting that they are not retained in serum and/or rapidly biotransformed into other forms. Twelve OH-PCBs, including several that are rarely reported (4,4'-diOH-PCB 202, 4'-OH-PCB 208, and 4-OH-PCB 163) were detected in over 60% of participants. Lastly, from repeated measures within subject serum for three OH-PCBs, concentrations of 4-OH-PCB 107 and 4-OH-PCB 187 changed significantly over three years of the study.

KEYWORDS:

Biomonitoring; Hydroxylated PCB; Longitudinal analysis; Metabolism; Polychlorinated biphenyl

PMID:
26774304
PMCID:
PMC4747419
[Available on 2017-03-01]
DOI:
10.1016/j.chemosphere.2015.12.113
[Indexed for MEDLINE]
Free PMC Article

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