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J Clin Virol. 2016 Jan;74:54-6. doi: 10.1016/j.jcv.2015.11.026. Epub 2015 Nov 26.

Fatal case of acute gastroenteritis with multiple viral coinfections.

Author information

1
Laboratory of Virology, University Hospital of Grenoble, Grenoble, France; CNRS, Unit for Virus Host-Cell Interactions, 38042 Grenoble, France; Université Grenoble Alpes, Unit for Virus Host-Cell Interactions, 38042 Grenoble, France. Electronic address: jlupo@chu-grenoble.fr.
2
Laboratory of Virology, University Hospital of Grenoble, Grenoble, France.
3
Department of Pediatrics, University Hospital of Grenoble, Grenoble, France.
4
Laboratory of Virology, University Hospital of Grenoble, Grenoble, France; CNRS, Unit for Virus Host-Cell Interactions, 38042 Grenoble, France; Université Grenoble Alpes, Unit for Virus Host-Cell Interactions, 38042 Grenoble, France.
5
National Reference Center for Enteric Viruses, Laboratory of Virology, University Hospital of Dijon, Dijon, France.

Abstract

We report a fatal case of acute gastroenteritis in a child with autism spectrum disorder. Multiple viral coinfections were detected by PCR in the patient's stool and digestive biopsy specimens. As viral detection is not necessarily associated with symptomatic disease, a semi-quantitative approach using cycle treshold values was proposed for the clinical interpretation of PCR. We discuss whether concomitant viral infections could be a risk factor for severe outcome in gastroenteritis cases. Individual risk factors are also addressed.

KEYWORDS:

Acute gastroenteritis; Autism spectrum disorder; Coinfection; Cycle threshold value; Enteric viruses; Viral load

PMID:
26655270
DOI:
10.1016/j.jcv.2015.11.026
[Indexed for MEDLINE]

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