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Trends Biochem Sci. 2016 Feb;41(2):119-121. doi: 10.1016/j.tibs.2015.11.010. Epub 2015 Dec 1.

A Door Opens for Fibrodysplasia Ossificans Progressiva.

Author information

1
Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241, Japan. Electronic address: katagiri@saitama-med.ac.jp.

Abstract

Fibrodysplasia ossificans progressiva (FOP), characterized by extra bone formation in soft tissues, is caused by a gain-of-function mutation in ACVR1, a transmembrane receptor. Recently, a potential treatment was developed by identifying a novel molecular mechanism underlying bone formation in FOP. These findings have opened the door to beating FOP.

KEYWORDS:

activin; bone morphogenetic protein (BMP); heterotopic ossification; intracellular signaling; ligand; receptor

PMID:
26654278
DOI:
10.1016/j.tibs.2015.11.010
[Indexed for MEDLINE]

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