Assessment of therapeutic options for reducing alkali burn-induced corneal neovascularization and inflammation

Alina Bakunowicz-Łazarczyk; Beata Urban

doi:10.1016/j.advms.2015.10.003

Assessment of therapeutic options for reducing alkali burn-induced corneal neovascularization and inflammation

Adv Med Sci. 2016 Mar;61(1):101-12. doi: 10.1016/j.advms.2015.10.003. Epub 2015 Nov 3.

Authors

Alina Bakunowicz-Łazarczyk¹, Beata Urban²

Affiliations

¹ Department of Pediatric Ophthalmology and Strabismus, Medical University of Bialystok, Bialystok, Poland.
² Department of Pediatric Ophthalmology and Strabismus, Medical University of Bialystok, Bialystok, Poland. Electronic address: urbanbea@umb.edu.pl.

PMID: 26651127
DOI: 10.1016/j.advms.2015.10.003

Abstract

This article aims to review and provide the current knowledge of the possibilities of topical treatment of corneal neovascularization due to alkali burns, evidenced by laboratory experiments, in vitro studies, and clinical trials published in the specialized literature. Authors present clinically relevant treatment of corneal neovascularization used in clinical practice, potential antiangiogenic topical therapeutics against corneal neovascularization, which are under investigation, and anti-angiogenic gene-therapy.

Keywords: Alkali burn; Corneal neovascularization; Treatment.

Publication types

Review

MeSH terms

Administration, Topical
Alkalies
Corneal Neovascularization / chemically induced*
Corneal Neovascularization / therapy*
Eye Burns / chemically induced*
Eye Burns / therapy*
Genetic Therapy
Humans
Inflammation / complications*
Inflammation / therapy*

Substances

Alkalies