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Nat Cell Biol. 2015 Dec;17(12):1519-21. doi: 10.1038/ncb3269.

Metabolic exit from naive pluripotency.

Author information

1
Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, California 92037, USA.

Abstract

Spatiotemporally distinct pluripotent states captured in vitro provide an accessible way of modelling early human development. An intricate interplay between the metabolome and histone modifications is now shown to drive the metabolic switch from human naive to primed pluripotency, one of the earliest steps of embryogenesis.

PMID:
26612574
DOI:
10.1038/ncb3269
[Indexed for MEDLINE]

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