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Blood Press. 2016 Jun;25(3):141-8. doi: 10.3109/08037051.2015.1111021. Epub 2015 Nov 20.

Androgenetic alopecia as an indicator of metabolic syndrome and cardiovascular risk.

Author information

1
a Department of Dermatology and Venereology , Kayseri Education and Research Hospital , Kayseri , Turkey ;
2
b Department of Cardiology , Sivas State Hospital , Sivas , Turkey ;
3
c Department of Dermatology and Venereology , Erciyes University Faculty of Medicine , Kayseri , Turkey ;
4
d Department of Cardiology , Erciyes University Faculty of Medicine , Kayseri , Turkey ;
5
e Department of Internal Medicine , Erciyes University Faculty of Medicine , Kayseri , Turkey ;
6
f Department of Dermatology and Venereology , Elazığ Education and Research Hospital , Elazığ , Turkey.

Abstract

Numerous studies have investigated a probable association between androgenetic alopecia (AGA) and cardiovascular disease (CVD) by researching limited and dispersed parameters. We aimed to evaluate both traditional and non-traditional cardiovascular risk factors in male patients with early-onset AGA. This case-control study included 68 participants: 51 male patients with early-onset AGA and 17 healthy male controls. Patients with AGA were classified into three groups according to the Hamilton-Norwood scale and the presence of vertex hair loss. Traditional and non-traditional cardiovascular risk factors were examined in all study subjects. Metabolic syndrome was diagnosed in 25 patients with AGA and in two control subjects (p < 0.05). The carotid intima-media thickness values were found to be significantly higher in patients with vertex pattern AGA than in patients without vertex baldness and controls (p < 0.05). The pulse-wave velocity values were also found to be significantly higher in patients (p < 0.001). A limitation of this study was the small study population. In conclusion, vertex pattern AGA appears to be a marker for early atherosclerosis. This finding supports the hypothesis that early-onset AGA alone could be an independent risk factor for CVD and metabolic syndrome.

KEYWORDS:

Androgenetic alopecia; arterial stiffness; cardiovascular risk factors; carotid intima–media thickness; insulin resistance; metabolic syndrome

PMID:
26585114
DOI:
10.3109/08037051.2015.1111021
[Indexed for MEDLINE]

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