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Sleep. 2015 Dec 1;38(12):1849-60. doi: 10.5665/sleep.5226.

Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions.

Author information

1
Department of Surgery, University of Michigan, Ann Arbor, MI.
2
Department of Medicine, Endocrinology Division, Feinberg School of Medicine, Northwestern University, Chicago, IL.
3
Department of Applied Mathematics & Statistics, Colorado School of Mines, Golden, CO.
4
Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, OR.
5
Institute for Cellular and Integrative Neuroscience, CNRS, University of Strasbourg, France.
6
Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA.
7
Department of Integrative Physiology, University of Colorado, Boulder, CO.
8
Departments of Internal Medicine, Pharmacology and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX.
9
Center for Integrative Genomics, University of Lausanne, Switzerland.
10
Department of Psychiatry, University of Arizona, Tucson, AZ.
11
Department of Medicine, The University of Chicago, Chicago, IL.
12
Department of Biology, University of Nevada, Reno, NV.
13
Department of Anesthesiology, Mayo Clinic, Rochester, MN.
14
Department of Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA.
15
Department of Medicine, Division of Endocrinology and Center for Clinical and Translational Sciences, University of Kentucky, Lexington, KY.
16
Center for Human Nutrition, Washington University School of Medicine in St. Louis, St. Louis, MO.
17
Division of Sleep Medicine/Department of Medicine and Center for Sleep and Circadian Neurobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
18
Regulatory Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA.
19
Department of Neurology, Howard Hughes Medical Institute, University of California, San Francisco, CA.
20
Department of Medicine, The Johns Hopkins University, Baltimore, MD.
21
Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, CA.
22
Department of Anesthesia, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
23
Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, MN.
24
Department of Biological Sciences, Missouri University of Science and Technology, Rolla, MO.
25
Sleep, Metabolism and Health Center, The University of Chicago, Chicago, IL.
26
Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO.

Abstract

A workshop was held at the National Institute for Diabetes and Digestive and Kidney Diseases with a focus on the impact of sleep and circadian disruption on energy balance and diabetes. The workshop identified a number of key principles for research in this area and a number of specific opportunities. Studies in this area would be facilitated by active collaboration between investigators in sleep/circadian research and investigators in metabolism/diabetes. There is a need to translate the elegant findings from basic research into improving the metabolic health of the American public. There is also a need for investigators studying the impact of sleep/circadian disruption in humans to move beyond measurements of insulin and glucose and conduct more in-depth phenotyping. There is also a need for the assessments of sleep and circadian rhythms as well as assessments for sleep-disordered breathing to be incorporated into all ongoing cohort studies related to diabetes risk. Studies in humans need to complement the elegant short-term laboratory-based human studies of simulated short sleep and shift work etc. with studies in subjects in the general population with these disorders. It is conceivable that chronic adaptations occur, and if so, the mechanisms by which they occur needs to be identified and understood. Particular areas of opportunity that are ready for translation are studies to address whether CPAP treatment of patients with pre-diabetes and obstructive sleep apnea (OSA) prevents or delays the onset of diabetes and whether temporal restricted feeding has the same impact on obesity rates in humans as it does in mice.

KEYWORDS:

circadian disruption; circadian rhythm; diabetes; insulin resistance; metabolism; obesity; short sleep; sleep apnea; sleep disorders

PMID:
26564131
PMCID:
PMC4667373
DOI:
10.5665/sleep.5226
[Indexed for MEDLINE]
Free PMC Article

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