Format

Send to

Choose Destination
Expert Opin Drug Discov. 2016;11(1):11-25. doi: 10.1517/17460441.2016.1115834. Epub 2015 Dec 2.

Improving treatment of neurodevelopmental disorders: recommendations based on preclinical studies.

Author information

1
a Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour , Radboud University Medical Centre , Nijmegen , The Netherlands.
2
b Department of Psychiatry, College of Medicine , University of Illinois at Chicago , Chicago , IL , USA.
3
c The International Stress and Behavior Society (ISBS) , Kiev , Ukraine.
4
d ZENEREI Research Center , Slidell , LA , USA.
5
e Department of Psychology , University of Southern Mississippi , Hattiesburg , MS , USA.
6
f Research Institute of Marine Drugs and Nutrition , College of Food Science and Technology, Guangdong Ocean University , Zhanjiang , Guangdong , China.
7
g Neuroscience Graduate Hospital , China Medical University Hospital , Taichung , Taiwan.
8
h Pavlov Physiology Department , Institute of Experimental Medicine , St. Petersburg , Russia.
9
i Department of Neuroscience, Psychology and Behaviour , University of Leicester , Leicester , UK.
10
j Department of Biological and Environmental Sciences , Troy University , Troy , AL , USA.
11
k Tokyo University of Agriculture and Technology , Tokyo , Japan.
12
l Departments of Pediatrics and Biochemistry , Saitama University Medical School , Saitama , Japan.
13
m Institute of Nutrition RAS , Moscow , Russia.
14
n Department of Cell Biology and Neurosciences , Istituto Superiore di Sanita , Rome , Italy.
15
o Department of Psychology , University of South Florida , Tampa , FL , USA.
16
p Research and Development Service , J.A. Haley Veterans Hospital , Tampa , FL , USA.
17
q Centre for Advanced Imaging , University of Queensland , Brisbane , Queensland , Australia.
18
r School of Health Sciences and Social Work , University of Portsmouth , Portsmouth , UK.
19
s Department of Psychology and Neuroscience , Dalhousie University , Halifax , Nova Scotia , Canada.
20
t Institute for Translational Biomedicine, St. Petersburg State University , St. Petersburg , Russia.
21
u Institute of Chemical Technology and Institute of Natural Sciences , Ural Federal University , Ekaterinburg , Russia.

Abstract

INTRODUCTION:

Neurodevelopmental disorders (NDDs) are common and severely debilitating. Their chronic nature and reliance on both genetic and environmental factors makes studying NDDs and their treatment a challenging task.

AREAS COVERED:

Herein, the authors discuss the neurobiological mechanisms of NDDs, and present recommendations on their translational research and therapy, outlined by the International Stress and Behavior Society. Various drugs currently prescribed to treat NDDs also represent a highly diverse group. Acting on various neurotransmitter and physiological systems, these drugs often lack specificity of action, and are commonly used to treat multiple other psychiatric conditions. There has also been relatively little progress in the development of novel medications to treat NDDs. Based on clinical, preclinical and translational models of NDDs, our recommendations cover a wide range of methodological approaches and conceptual strategies.

EXPERT OPINION:

To improve pharmacotherapy and drug discovery for NDDs, we need a stronger emphasis on targeting multiple endophenotypes, a better dissection of genetic/epigenetic factors or "hidden heritability," and a careful consideration of potential developmental/trophic roles of brain neurotransmitters. The validity of animal NDD models can be improved through discovery of novel (behavioral, physiological and neuroimaging) biomarkers, applying proper environmental enrichment, widening the spectrum of model organisms, targeting developmental trajectories of NDD-related behaviors and comorbid conditions beyond traditional NDDs. While these recommendations cannot be addressed all in once, our increased understanding of NDD pathobiology may trigger innovative cross-disciplinary research expanding beyond traditional methods and concepts.

KEYWORDS:

ADHD; animal models; autism; neurodevelopmental disorders; translational research

PMID:
26558752
DOI:
10.1517/17460441.2016.1115834
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center