Deficiency of respiratory chain complex I in Hashimoto thyroiditis

Mitochondrion. 2016 Jan:26:1-6. doi: 10.1016/j.mito.2015.11.002. Epub 2015 Nov 7.

Abstract

Oncocytic cells (OCs) are characterized by an accumulation of mitochondria and their occurrence in the thyroid gland of patients with Hashimoto thyroiditis (HT) is well known. However, their properties and functional relevance are poorly understood. We investigated OC lesions (n=212) in the thyroid of 12 HT patients. Loss of complex I protein was observed in oncocytic lesions of each of the patients. In addition to isolated complex I deficiency, 25% of oncocytic lesions showed combined deficiency of complex I and IV. Thus, we demonstrate for the first time a defect of respiratory chain complex I in OCs of HT patients.

Keywords: Autoimmune disease; Hashimoto thyroiditis; Mitochondria; Oncocytic cell; Respiratory chain complex I.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Electron Transport Complex I / deficiency*
  • Female
  • Hashimoto Disease / epidemiology*
  • Hashimoto Disease / pathology
  • Humans
  • Middle Aged
  • Mitochondria / enzymology*
  • Mitochondria / pathology
  • Thyroid Gland / enzymology*
  • Thyroid Gland / pathology

Substances

  • Electron Transport Complex I