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Prev Vet Med. 2015 Dec 1;122(3):298-305. doi: 10.1016/j.prevetmed.2015.10.008. Epub 2015 Oct 21.

A new compartmental model of Mycobacterium avium subsp. paratuberculosis infection dynamics in cattle.

Author information

1
Department of Pathobiology, University of Illinois College of Veterinary Medicine, Urbana, IL 61802, USA. Electronic address: rlsdvm@illinois.edu.
2
GD-Animal Health, Deventer, The Netherlands. Electronic address: yschukken@cornell.edu.
3
Department of Population Medicine and Diagnostic Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY 14850, USA. Electronic address: ytg1@cornell.edu.

Abstract

Models of Mycobacterium avium subsp. paratuberculosis (MAP), a chronic infectious agent of cattle, are used to identify effective control programs. However, new biological findings show that adult infections occur and that infected animals can be separated into 2 paths: animals that will become high-shedding and, eventually, experience clinical disease (high-path); and animals that will shed only small quantities of MAP and will remain subclinical (low-path). Longitudinal data analysis found that high-path animals progress more quickly than previously believed. A standard model of MAP transmission in dairy herds was modified to include adult low-path infections and 2 infection pathways for infected calves. Analysis of this model showed that adult infection may play an important role in MAP dynamics on a dairy farm, and that the increased rate of progression for high-path animals influences both the prevalence and the persistence of MAP on a dairy farm. This new model will be able to determine the effectiveness of MAP control programs more accurately than previous models.

KEYWORDS:

Control; Disease modeling; Mycobacteria; Paratuberculosis; Persistence

PMID:
26520176
PMCID:
PMC4679433
DOI:
10.1016/j.prevetmed.2015.10.008
[Indexed for MEDLINE]
Free PMC Article

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