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Environ Toxicol Pharmacol. 2015 Nov;40(3):931-5. doi: 10.1016/j.etap.2015.10.002. Epub 2015 Oct 23.

The influence of oxidative stress induced by iron on telomere length.

Author information

1
Department of Biomedical and Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland. Electronic address: zalewska.m@gmail.com.
2
Students Scientific Society at the Department of Biomedical Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland.
3
Department of Biomedical and Environmental Analysis, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland.

Abstract

Oxidative stress can be induced by increased concentrations of iron in the body and consequently can cause shortening of telomeres. Telomeres, called mitotic clocks, are non-coding fragments at the end of chromosomes. During the replication of genetic material they are shortened, playing the role of ageing biomarkers in eukaryotes. In human endothelial cells, oxidative stress causes a decrease in telomerase activity. Shortening of chromosomes in telomeric parts was found in patients with primary hemochromatosis and in patients taking supplements containing iron. Increased level of transferrin saturation is associated with the presence of shorter telomeres in the chromosomes of leukocytes. The relationship between iron status and telomere length is still not fully understood.

KEYWORDS:

Iron; Oxidative stress; Telomere shortening

PMID:
26513689
DOI:
10.1016/j.etap.2015.10.002
[Indexed for MEDLINE]

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