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Leuk Lymphoma. 2016;57(6):1450-9. doi: 10.3109/10428194.2015.1094693. Epub 2015 Nov 16.

Risk of multiple myeloma in a case-spouse study.

Author information

1
a Division of Cancer Epidemiology and Genetics , National Cancer Institute, NIH, DHHS , Rockville , MD , USA ;
2
b International Myeloma Foundation , Hollywood , CA , USA ;
3
c Cancer Research and Biostatistics , Seattle , WA , USA ;
4
d Cancer Center, University of Minnesota , Minneapolis , MN , USA ;
5
e Haemato-Oncology, Institute of Cancer Research , Sutton , UK ;
6
f Cedar Sinai Medical Center , Los Angeles , CA , USA.

Abstract

This study examined lifestyle, occupation, medical history and medication use with multiple myeloma risk in a case-spouse study (481 patients, 351 spouses). Odds ratios (ORs) and 95% confidence intervals (CI) were calculated using logistic regression. Compared to spouse controls, cases were more likely to have a family history of multiple myeloma (OR = 2.8, 95% CI = 1.2-6.4) and smoked cigarettes (OR = 1.7, 95% CI = 1.2-2.5), but less likely to have consumed alcohol (OR = 0.6, 95% CI = 0.4-0.9). Nurse/health practitioners (OR = 2.8, 95% CI = 1.3-6.2) and production workers (OR = 3.7, 95% CI = 1.0-13.7) had significantly increased risks; and some occupations linked to diesel exhaust had elevated, but non-significant, risks. History of herpes simplex (OR = 1.7, 95% CI = 1.2-2.4), shingles (OR = 1.7, 95% CI = 1.1-2.7), sexually transmitted diseases (OR = 2.0, 95% CI = 1.0-3.7) and medication allergies (OR = 1.7, 95% CI = 1.2-2.4) were associated with higher risks. Use of angiotensin-converting enzyme inhibitors, anti-convulsants, antidepressants, statins and diuretics were associated with reduced risks. The results are consistent with previous population-based studies and support the utility of patient databanks and spouse controls as a resource in epidemiologic research.

KEYWORDS:

Myeloma; case–spouse; epidemiology

PMID:
26422532
DOI:
10.3109/10428194.2015.1094693
[Indexed for MEDLINE]

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