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Rejuvenation Res. 2016 Jun;19(3):195-203. doi: 10.1089/rej.2015.1737. Epub 2016 Feb 10.

Interaction Between the FOXO1A-209 Genotype and Tea Drinking Is Significantly Associated with Reduced Mortality at Advanced Ages.

Author information

1
1 Center for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University , Durham, North Carolina.
2
2 Center for Healthy Aging and Development Studies, National School of Development, Peking University , Beijing, China .
3
3 Department of Management, Business School of Xiangtan University , Xiangtan, China .
4
4 State Key Laboratory of Genetics Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University , Shanghai, China .
5
5 Department of Agriculture Economics. Renmin University of China , Beijing, China .
6
6 Beijing Genomics Institute (BGI)-Shenzhen , Shenzhen, China .
7
7 Department of Psychological Medicine, National University of Singapore , Singapore .
8
8 Lieber Institute for Brain Development, Johns Hopkins University , Baltimore, Maryland.
9
9 Department of Sociology, Peking University , Beijing, China .
10
10 Department of Human Population Genetics, Institute of Molecular Medicine, Peking University , Beijing, China .
11
11 School of Life Sciences, Peking University , Beijing, China .
12
12 Duke Molecular Physiology Institute, Duke University , Durham, North Carolina.
13
13 Department of Neurology, Medical Center, Duke University , Durham, North Carolina.
14
14 Population Research Institute, Duke University , Durham, North Carolina.
15
15 Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark , Odense, Denmark .
16
16 National Institute of Geriatrics, Beijing Hospital , Ministry of Health of China, Beijing, China .
17
17 Department of Biomedicine, Aarhus University , Aarhus, Denmark .
18
18 Center for Genetic & Genomic Medicine, Zhejiang University School of Medicine , Hangzhou, China .
19
19 James D. Watson Institute of Genome Sciences , Hangzhou, China .
20
20 Princess Al-Jawhara Centre of Excellence in Research of Hereditary Disorders, King Abdulaziz University , Jeddah, Saudi Arabia .
21
21 School of Medicine, Zhejiang University , Hangzhou, China .
22
22 Department of Human Welfare, Okinawa International University , Ginowan, Japan .
23
23 Department of Research, Kuakini Medical Center and Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii , Hawaii.
24
24 Max Planck Institute for Demographic Research , Rostock, Germany .

Abstract

On the basis of the genotypic/phenotypic data from Chinese Longitudinal Healthy Longevity Survey (CLHLS) and Cox proportional hazard model, the present study demonstrates that interactions between carrying FOXO1A-209 genotypes and tea drinking are significantly associated with lower risk of mortality at advanced ages. Such a significant association is replicated in two independent Han Chinese CLHLS cohorts (p = 0.028-0.048 in the discovery and replication cohorts, and p = 0.003-0.016 in the combined dataset). We found the associations between tea drinking and reduced mortality are much stronger among carriers of the FOXO1A-209 genotype compared to non-carriers, and drinking tea is associated with a reversal of the negative effects of carrying FOXO1A-209 minor alleles, that is, from a substantially increased mortality risk to substantially reduced mortality risk at advanced ages. The impacts are considerably stronger among those who carry two copies of the FOXO1A minor allele than those who carry one copy. On the basis of previously reported experiments on human cell models concerning FOXO1A-by-tea-compounds interactions, we speculate that results in the present study indicate that tea drinking may inhibit FOXO1A-209 gene expression and its biological functions, which reduces the negative impacts of FOXO1A-209 gene on longevity (as reported in the literature) and offers protection against mortality risk at oldest-old ages. Our empirical findings imply that the health outcomes of particular nutritional interventions, including tea drinking, may, in part, depend upon individual genetic profiles, and the research on the effects of nutrigenomics interactions could potentially be useful for rejuvenation therapies in the clinic or associated healthy aging intervention programs.

PMID:
26414954
PMCID:
PMC4931303
DOI:
10.1089/rej.2015.1737
[Indexed for MEDLINE]
Free PMC Article

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