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Future Oncol. 2015;11(21):2937-47. doi: 10.2217/fon.15.236. Epub 2015 Sep 28.

Stereotactic body radiotherapy for head and neck cancer: an addition to the armamentarium against head and neck cancer.

Author information

1
Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Science Centre, University of Toronto, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada.
2
Department of Otolaryngology, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, M4N 3M5, Toronto, ON, Canada.
3
Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, 11100 Euclid Avenue, LTR B181, Cleveland, OH, USA.

Abstract

In the recent years, stereotactic body radiation therapy (SBRT) has emerged as a potential therapy for head and neck malignancies. Although early results appear to be promising, serious acute and late effects have been observed, mainly in patients who have had prior external beam radiotherapy. This review will discuss the radiobiology of SBRT, clinical rationale and outcomes for SBRT in head and neck cancers and focus on the benefits and potential limitations in both de novo and re-irradiation settings.

KEYWORDS:

carotid blowout; head and neck cancer; local control; overall survival; radiobiology; re-irradiation; stereotactic body radiotherapy; toxicity

PMID:
26414213
DOI:
10.2217/fon.15.236
[Indexed for MEDLINE]

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