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J Infect Dis. 2016 Feb 15;213(4):628-33. doi: 10.1093/infdis/jiv455. Epub 2015 Sep 15.

HIV Disrupts Human T Cells That Target Mycobacterial Glycolipids.

Author information

  • 1KwaZulu-Natal Research Institute for Tuberculosis and HIV, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal Ragon Institute of MGH, MIT, and Harvard, Cambridge.
  • 2Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  • 3KwaZulu-Natal Research Institute for Tuberculosis and HIV, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal Ragon Institute of MGH, MIT, and Harvard, Cambridge Max Planck Institute for Infection Biology, Berlin, Germany.
  • 4Infectious Diseases Unit, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal McCord Hospital, Durban, South Africa.

Abstract

Single-cell analysis captures the heterogeneity of T-cell populations that target defined antigens. Human immunodeficiency virus (HIV) infection results in defects of antimycobacterial immunity, which remain poorly defined. We therefore recruited a small number of subjects, including those with latent and active M. tuberculosis infection, with or without concomitant HIV infection, and tracked the mycobacterial glycolipid-reactive T-cell repertoire by using CD1b tetramers. Glycolipid-reactive T cells expressed memory markers and the HIV coreceptors CD4 and CCR5; they were not detected in subjects with HIV-associated active M. tuberculosis infection. HIV infection may affect T cells that recognize mycobacterial glycolipids and influence immunity.

KEYWORDS:

CD1; HIV; T cell; antigens; glycolipids; tetramer; tuberculosis

PMID:
26374910
PMCID:
PMC4721911
DOI:
10.1093/infdis/jiv455
[PubMed - indexed for MEDLINE]
Free PMC Article
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