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Odontology. 2016 Sep;104(3):329-37. doi: 10.1007/s10266-015-0215-4. Epub 2015 Aug 12.

Clinical, radiographic, and histologic analysis of the effects of acemannan used in direct pulp capping of human primary teeth: short-term outcomes.

Author information

1
Dental Biomaterials Science Program, Graduate School, Chulalongkorn University, Bangkok, Thailand.
2
Department of Pediatric Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
3
Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
4
Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
5
Research Unit of Herbal Medicine, Biomaterial, and Material for Dental Treatment, Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Henri-Dunant Rd, Patumwan, Bangkok, 10330, Thailand. pthunyak@yahoo.com.

Abstract

Acemannan has been previously reported as a direct pulp-capping agent in animal study. This natural material demonstrated its biocompatibility and enhanced reparative dentin formation. The objective of this study was to investigate the action of acemannan as a direct pulp-capping material in human primary teeth with deep caries. Forty-two deeply carious mandibular primary molars from 37 children, aged 7-11 years old diagnosed with reversible pulpitis were studied. After completely removing the infected dentine, teeth with a pinpoint pulpal exposure were randomly divided into two treatment groups: acemannan or calcium hydroxide. A glass-ionomer cement base was applied to all teeth prior to restoration with stainless steel crowns. Clinical and radiographic evaluation was performed 6 months post-treatment. The teeth due to exfoliate were extracted and histopathologically evaluated for inflammation, dentine bridge formation, and soft tissue organization. At 6 months, the overall clinical and radiographic success rates of direct pulp capping with acemannan and calcium hydroxide at 6 months were 72.73 and 70.0 %, respectively. The histopathological results indicated that the acemannan-treated group had significantly better histopathological responses compared with the calcium hydroxide-treated group (p < 0.05). These data suggest acemannan offers a valuable alternative biomaterial for vital pulp therapy in primary teeth.

KEYWORDS:

Acemannan; Aloe vera; Biomaterial; Clinical study; Histopathological evaluation; Vital pulp therapy

PMID:
26264630
DOI:
10.1007/s10266-015-0215-4
[Indexed for MEDLINE]

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