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Appl Physiol Nutr Metab. 2015 Aug;40(8):846-9. doi: 10.1139/apnm-2015-0039.

Cholesterol ester transfer protein polymorphism rs5882 is associated with triglyceride-lowering in response to plant sterol consumption.

Author information

1
a Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB R3T 6C5, Canada.
2
b Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
3
c Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY 14214, USA.
4
d United States Department of Agriculture (USDA), Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, MD 20705, USA.
5
e Department of Food Science, University of Manitoba, Winnipeg, MB R3T 6C5, Canada.

Abstract

Recent work suggests that plant sterol (PS) consumption may lower triglyceride (TG) concentrations; however, human clinical trial evidence is inconsistent. We associated SNP r5882 in cholesteryl ester transfer protein with changes in TG concentrations following PS consumption (2 g/day for 4 weeks) in a dual-centre, single-blind, randomized, crossover trial. TG concentrations were lowered in homozygotes for the minor G-allele of rs5882 (-0.46 ± 0.13 mmol/L, p = 0.002, n = 10); there was no effect in the A-allele carriers.

KEYWORDS:

CETP; nutrigenetics; nutrigénétique; phytosterols; phytostérols; plant sterols; stérols végétaux; triglycerides; triglycérides

PMID:
26244602
DOI:
10.1139/apnm-2015-0039
[Indexed for MEDLINE]

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