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J Mol Histol. 2015 Oct;46(4-5):439-42. doi: 10.1007/s10735-015-9634-3. Epub 2015 Jul 25.

Evidence for the presence of clofazimine and its distribution in the healthy mouse brain.

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  • 1Catalysis and Peptide Research Unit, School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Westville Campus, Durban, South Africa.

Abstract

This is the first report of clofazimine (CFZ) penetration and distribution in normal mouse brain. Mice were administered 25 mg/kg CFZ or 100 mg/kg CFZ orally, daily for 2 weeks. Animals were sacrificed and blood and brain tissues were harvested. Liquid chromatography tandem mass spectrometry showed high concentrations of CFZ in homogenized brain, with 100 mg/kg dose having significantly higher concentration than 25 mg/kg. Matrix-assisted laser desorption/ionization spectrometric imaging of brain sections showed widespread tissue distribution of CFZ. Our results show dose dependent localization in brain.

PMID:
26208572
DOI:
10.1007/s10735-015-9634-3
[PubMed - indexed for MEDLINE]
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