Format

Send to

Choose Destination
Nat Neurosci. 2015 Aug;18(8):1077-80. doi: 10.1038/nn.4054. Epub 2015 Jun 29.

Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions.

Author information

1
1] Gladstone Institute of Neurological Disease, University of California, San Francisco, California, USA. [2] Institute of Anatomy and Cell Biology, Department of Molecular Embryology, University of Freiburg, Freiburg, Germany.
2
Gladstone Institute of Neurological Disease, University of California, San Francisco, California, USA.
3
1] Institute of Anatomy and Cell Biology, Department of Molecular Embryology, University of Freiburg, Freiburg, Germany. [2] Faculty of Biology, University of Freiburg, Freiburg, Germany.
4
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA.
5
1] Department of Neurosciences, University of California, San Diego, La Jolla, California, USA. [2] National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, California, USA.
6
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
7
1] Life Imaging Center, Center for Biological Systems Analysis, University of Freiburg, Freiburg, Germany. [2] BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany.
8
Institute of Pharmaceutical Science, King's College London, London, UK.
9
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
10
1] Gladstone Institute of Neurological Disease, University of California, San Francisco, California, USA. [2] Department of Neurology, University of California, San Francisco, San Francisco, California, USA.

Abstract

Astrocytes modulate neuronal activity and inhibit regeneration. We show that cleaved p75 neurotrophin receptor (p75(NTR)) is a component of the nuclear pore complex (NPC) required for glial scar formation and reduced gamma oscillations in mice via regulation of transforming growth factor (TGF)-β signaling. Cleaved p75(NTR) interacts with nucleoporins to promote Smad2 nucleocytoplasmic shuttling. Thus, NPC remodeling by regulated intramembrane cleavage of p75(NTR) controls astrocyte-neuronal communication in response to profibrotic factors.

PMID:
26120963
PMCID:
PMC4878404
DOI:
10.1038/nn.4054
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center