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Ann Biomed Eng. 2015 Dec;43(12):2911-23. doi: 10.1007/s10439-015-1355-y. Epub 2015 Jun 25.

Neural Tissue Motion Impacts Cerebrospinal Fluid Dynamics at the Cervical Medullary Junction: A Patient-Specific Moving-Boundary Computational Model.

Author information

  • 1Conquer Chiari Research Center, Department of Mechanical Engineering, The University of Akron, Akron, OH, 44325-3903, USA.
  • 2Department of Mechanical Engineering, The University of Akron, Akron, OH, USA.
  • 3Department of Pediatric Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH, USA.
  • 4Department of Radiology, Emory University, Atlanta, GA, USA.
  • 5Conquer Chiari Research Center, Department of Mechanical Engineering, The University of Akron, Akron, OH, 44325-3903, USA. director@chiari-research.org.
  • 6Department of Mechanical Engineering, The University of Akron, Akron, OH, USA. director@chiari-research.org.

Abstract

Central nervous system (CNS) tissue motion of the brain occurs over 30 million cardiac cycles per year due to intracranial pressure differences caused by the pulsatile blood flow and cerebrospinal fluid (CSF) motion within the intracranial space. This motion has been found to be elevated in type 1 Chiari malformation. The impact of CNS tissue motion on CSF dynamics was assessed using a moving-boundary computational fluid dynamics (CFD) model of the cervical-medullary junction (CMJ). The cerebellar tonsils and spinal cord were modeled as rigid surfaces moving in the caudocranial direction over the cardiac cycle. The CFD boundary conditions were based on in vivo MR imaging of a 35-year old female Chiari malformation patient with ~150-300 µm motion of the cerebellar tonsils and spinal cord, respectively. Results showed that tissue motion increased CSF pressure dissociation across the CMJ and peak velocities up to 120 and 60%, respectively. Alterations in CSF dynamics were most pronounced near the CMJ and during peak tonsillar velocity. These results show a small CNS tissue motion at the CMJ can alter CSF dynamics for a portion of the cardiac cycle and demonstrate the utility of CFD modeling coupled with MR imaging to help understand CSF dynamics.

KEYWORDS:

Central nervous system; Cerebrospinal fluid; Computational fluid dynamics; Moving boundary simulation

PMID:
26108203
PMCID:
PMC4626272
DOI:
10.1007/s10439-015-1355-y
[PubMed - indexed for MEDLINE]
Free PMC Article
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