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Elife. 2015 Jun 23;4:e06513. doi: 10.7554/eLife.06513.

Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants.

Author information

1
Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, United States.
2
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.
3
Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, United States.

Abstract

Electroencephalogram (EEG) approaches may provide important information about developmental changes in brain-state dynamics during general anesthesia. We used multi-electrode EEG, analyzed with multitaper spectral methods and video recording of body movement to characterize the spatio-temporal dynamics of brain activity in 36 infants 0-6 months old when awake, and during maintenance of and emergence from sevoflurane general anesthesia. During maintenance: (1) slow-delta oscillations were present in all ages; (2) theta and alpha oscillations emerged around 4 months; (3) unlike adults, all infants lacked frontal alpha predominance and coherence. Alpha power was greatest during maintenance, compared to awake and emergence in infants at 4-6 months. During emergence, theta and alpha power decreased with decreasing sevoflurane concentration in infants at 4-6 months. These EEG dynamic differences are likely due to developmental factors including regional differences in synaptogenesis, glucose metabolism, and myelination across the cortex. We demonstrate the need to apply age-adjusted analytic approaches to develop neurophysiologic-based strategies for pediatric anesthetic state monitoring.

KEYWORDS:

EEG; alpha; anesthesia; computational biology; development; human; infant; neuroscience; sevoflurane; systems biology

PMID:
26102526
PMCID:
PMC4502759
DOI:
10.7554/eLife.06513
[Indexed for MEDLINE]
Free PMC Article

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