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Cell. 2015 Jun 18;161(7):1502-4. doi: 10.1016/j.cell.2015.06.005.

Linking Micronuclei to Chromosome Fragmentation.

Author information

1
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies 10010 North Torrey Pines Road, La Jolla, 92037 CA, USA.
2
Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies 10010 North Torrey Pines Road, La Jolla, 92037 CA, USA. Electronic address: hetzer@salk.edu.

Abstract

Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei frequently undergo chromothripsis-like rearrangements in the subsequent cell cycle.

PMID:
26091034
DOI:
10.1016/j.cell.2015.06.005
[Indexed for MEDLINE]
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