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J Immunol Res. 2015;2015:673503. doi: 10.1155/2015/673503. Epub 2015 May 18.

Decreased Frequency of Circulating Myelin Oligodendrocyte Glycoprotein B Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis.

Author information

1
INSERM, UMR1064, 44093 Nantes, France ; Faculté de Médecine, Université de Nantes, 44035 Nantes, France.
2
INSERM, UMR1064, 44093 Nantes, France ; Service de Neurologie, CHU de Nantes, 44093 Nantes, France.
3
Clinical Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria.
4
INSERM, UMR1064, 44093 Nantes, France.
5
INSERM, CIC 004, 44093 Nantes, France.
6
Faculté de Médecine, Université de Nantes, 44035 Nantes, France.
7
INSERM, UMR1064, 44093 Nantes, France ; Faculté de Médecine, Université de Nantes, 44035 Nantes, France ; Service de Neurologie, CHU de Nantes, 44093 Nantes, France.

Abstract

Although there is no evidence for a role of anti-MOG antibodies in adult MS, no information on B lymphocytes with MOG-committed BCR is available. We report here on the frequency of anti-MOG B cells forming rosettes with polystyrene beads (BBR) covalently bound to the extracellular domain of rhMOG in 38 relapsing-remitting patients (RRMS) and 50 healthy individuals (HI). We show a substantial proportion of circulating anti-MOG-BBR in both RRMS and HI. Strikingly, MOG-specific B cells frequencies were lower in MS than in HI. Anti-MOG antibodies measured by a cell-based assay were not different between MS patients and controls, suggesting a specific alteration of anti-MOG B cells in MS. Although anti-MOG-BBR were higher in CNS fluid than in blood, no difference was observed between MS and controls. Lower frequency of MOG-BBR in MS was not explained by an increased apoptosis, but a trend for lower proliferative capacity was noted. Despite an efficient B cell transmigration across brain derived endothelial cells, total and anti-MOG B cells transmigration was similar between MS and HI. The striking alteration in MOG-specific B cells, independent of anti-MOG antibody titers, challenges our view on the role of MOG-specific B cells in MS.

PMID:
26090495
PMCID:
PMC4452172
DOI:
10.1155/2015/673503
[Indexed for MEDLINE]
Free PMC Article

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