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Front Nutr. 2015 May 27;2:16. doi: 10.3389/fnut.2015.00016. eCollection 2015.

Impact of Nutrition on Non-Coding RNA Epigenetics in Breast and Gynecological Cancer.

Author information

1
Department of Biology, University of Alabama at Birmingham , Birmingham, AL , USA ; Department of Biochemistry, University of Leipzig , Leipzig , Germany.
2
Department of Biology, University of Alabama at Birmingham , Birmingham, AL , USA ; Comprehensive Center for Healthy Ageing, University of Alabama at Birmingham , Birmingham, AL , USA ; Comprehensive Cancer Center, University of Alabama at Birmingham , Birmingham, AL , USA ; Nutrition Obesity Research Center, University of Alabama at Birmingham , Birmingham, AL , USA ; Comprehensive Diabetes Center, University of Alabama at Birmingham , Birmingham, AL , USA.

Abstract

Cancer is the second leading cause of death in females. According to the American Cancer Society, there are 327,660 new cases in breast and gynecological cancers estimated in 2014, placing emphasis on the need for cancer prevention and new cancer treatment strategies. One important approach to cancer prevention involves phytochemicals, biologically active compounds derived from plants. A variety of studies on the impact of dietary compounds found in cruciferous vegetables, green tea, and spices like curry and black pepper have revealed epigenetic changes in female cancers. Thus, an important emerging topic comprises epigenetic changes due to the modulation of non-coding RNA levels. Since it has been shown that non-coding RNAs such as microRNAs and long non-coding RNAs are aberrantly expressed in cancer, and furthermore are linked to distinct cancer phenotypes, understanding the effects of dietary compounds and supplements on the epigenetic modulator non-coding RNA is of great interest. This article reviews the current findings on nutrition-induced changes in breast and gynecological cancers at the non-coding RNA level.

KEYWORDS:

diet; epigenetics; female cancer; microRNA; non-coding RNA

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