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Nat Neurosci. 2015 Jul;18(7):962-4. doi: 10.1038/nn.4034. Epub 2015 Jun 1.

Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress.

Author information

1
1] Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
2
Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
3
1] Fishberg Department of Neuroscience, Friedman Brain Institute Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Department of Pharmacology and Systems Therapeutics, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
4
Department of Pharmacology and Systems Therapeutics, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
5
Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockefeller University, New York, New York, USA.
6
Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
7
1] Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA. [2] Department of Bioengineering, Stanford University, Stanford, California, USA.

Abstract

Postsynaptic remodeling of glutamatergic synapses on ventral striatum (vSTR) medium spiny neurons (MSNs) is critical for shaping stress responses. However, it is unclear which presynaptic inputs are involved. Susceptible mice exhibited increased synaptic strength at intralaminar thalamus (ILT), but not prefrontal cortex (PFC), inputs to vSTR MSNs following chronic social stress. Modulation of ILT-vSTR versus PFC-vSTR neuronal activity differentially regulated dendritic spine plasticity and social avoidance.

PMID:
26030846
PMCID:
PMC4482771
DOI:
10.1038/nn.4034
[Indexed for MEDLINE]
Free PMC Article

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