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Clin Microbiol Infect. 2015 Sep;21(9):874.e1-8. doi: 10.1016/j.cmi.2015.05.015. Epub 2015 May 21.

Relationship between GII.3 norovirus infections and blood group antigens in young children in Tunisia.

Author information

1
National Reference Centre for Enteric Viruses, Public Hospital of Dijon, France; Laboratory of Infectious Diseases and Biological Agents, Faculty of Pharmacy, Monastir, Tunisia.
2
National Reference Centre for Enteric Viruses, Public Hospital of Dijon, France.
3
Laboratory of Infectious Diseases and Biological Agents, Faculty of Pharmacy, Monastir, Tunisia.
4
Epidemiology and Infection Control Unit, Public Hospital of Dijon, Dijon, France.
5
Paediatric Department, University Hospital Fattouma Bourguiba, Monastir, Tunisia.
6
National Reference Centre for Enteric Viruses, Public Hospital of Dijon, France. Electronic address: gael.belliot@u-bourgogne.fr.

Abstract

Noroviruses (NoVs) constitute a major cause of gastroenteritis in Tunisia. One hundred and fourteen matched saliva and stool samples were collected from children (n = 114) suffering from acute gastroenteritis at the hospital of Monastir during the winter season 2011-2012. For 98 of 114 children, blood samples were collected for secretor genotyping. NoVs were associated with 36.8% (n = 42/114) of the gastroenteritis cases. The GII.3 genotype was the most common (69% of all NoVs). For patients who were phenotyped (n = 114) for human blood group antigens (HBGAs), the secretor and non-secretor phenotypes represented 79% and 21%, respectively. Of the NoV infections, 83% were detected in all ABO groups. Five GII.3 isolates, one GII.1 isolate and one GII.7 isolate were detected in Lewis-positive non-secretors, confirmed by genotyping of the FUT2 gene. Even though our data showed that GII.3 NoVs could infect non-secretors, no binding was observed with saliva and GII.3 baculovirus-expressed virus-like particles from the same symptomatic non-secretor individual. This suggests that other factors might also participate in NoV attachment in children and newborns.

KEYWORDS:

Children; HBGA; gastroenteritis; infection; norovirus; receptor

PMID:
26003283
DOI:
10.1016/j.cmi.2015.05.015
[Indexed for MEDLINE]
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