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Curr Opin Clin Nutr Metab Care. 2015 Jul;18(4):328-33. doi: 10.1097/MCO.0000000000000180.

Nutriepigenomics: the role of nutrition in epigenetic control of human diseases.

Author information

1
aDepartment of Nutritional Sciences, University Vienna, Vienna, Austria bDepartment of Nutrition Science, Purdue University, West Lafaytte, Indiana, USA cDepartment of Gynecology and Obstetrics, Clinical Institute of Medical Genetics, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Abstract

PURPOSE OF REVIEW:

Nutrients or even diets affect the epigenome by lifelong remodeling. Nutritional imbalances are associated with noncommunicable diseases. Thus, nutriepigenomics is a promising field in the treatment of complex human diseases.

RECENT FINDINGS:

The epigenome is susceptible to changes and can be shaped by nutritional states, especially in prenatal period through transgenerational mechanisms and in early postnatal life when critical developmental processes are taking place. Although more stable, the epigenetic marks in adulthood are also dynamic and modifiable by environmental factors including diet.

SUMMARY:

The present review is focused on the most recent knowledge of epigenetically active nutrients/diets including transgenerational inheritance and prenatal predispositions related to increased risk for cancer, metabolic syndrome, and neurodegenerative diseases.

PMID:
26001651
DOI:
10.1097/MCO.0000000000000180
[Indexed for MEDLINE]

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