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Curr Biol. 2015 May 18;25(10):R418-20. doi: 10.1016/j.cub.2015.03.019.

Tumor Metabolism: MAGE-A Proteins Help TRIM Turn Over AMPK.

Author information

1
Molecular and Cell Biology Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: shaw@salk.edu.

Abstract

MAGE-A proteins are testis-specific E3 ubiquitin ligase components whose expression is upregulated in many cancers. MAGE-A3 and -A6 act as oncogenes and recent work now shows that they degrade the central metabolic regulator AMPK, providing a novel mechanism for rewiring cancer metabolism.

PMID:
25989082
DOI:
10.1016/j.cub.2015.03.019
[Indexed for MEDLINE]
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