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IUBMB Life. 2015 Apr;67(4):239-54. doi: 10.1002/iub.1366. Epub 2015 Apr 21.

Prohibitin 2: At a communications crossroads.

Author information

1
Laboratory of Musculoskeletal Cell Biology, Rizzoli Orthopedic Institute, Bologna, Italy.
2
Laboratory RAMSES, Rizzoli Orthopedic Institute, Bologna, Italy.
3
Department of Biomedical Sciences, University of Bologna, Bologna, Italy.
4
National Research Council of Italy, Institute of Molecular Genetics, Bologna, Italy.

Abstract

Prohibitins (PHBs) are a highly conserved class of proteins first discovered as inhibitors of cellular proliferation. Since then PHBs have been found to have a significant role in transcription, nuclear signaling, mitochondrial structural integrity, cell division, and cellular membrane metabolism, placing these proteins among the key regulators of pathologies such as cancer, neuromuscular degeneration, and other metabolic diseases. The human genome encodes two PHB proteins, prohibitin 1 (PHB1) and prohibitin 2 (PHB2), which function not only as a heterodimeric complex, but also independently. While many previous reviews have focused on the better characterized prohibitin, PHB1, this review focuses on PHB2 and new data concerning its cellular functions both in complex with PHB1 and independent of PHB1.

KEYWORDS:

AKT; Alzheimer's; CaMK IV; cancer; diabetes; differentiation; gene regulation; inflammation; mitochondria; myositis; nucleus; plasma membrane receptors; prohibitin; stress; transcription

PMID:
25904163
DOI:
10.1002/iub.1366
[Indexed for MEDLINE]
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