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Presse Med. 2015 Apr;44(4 Pt 2):e103-12. doi: 10.1016/j.lpm.2015.02.009. Epub 2015 Mar 23.

The autoimmune concept of multiple sclerosis.

Author information

1
CHU de Nantes, service de neurologie, Inserm CR1064, 44093 Nantes cedex, France.
2
CHU de Nantes, service de neurologie, Inserm CR1064, 44093 Nantes cedex, France. Electronic address: david.laplaud@univ-nantes.fr.
3
Max Planck institute of neurobiology, department of neuroimmunology, Planegg-Martinsried, 31, 81377 Munich, Germany.

Abstract

Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system (CNS). With growing evidence for environmental and genetic factors, MS is now accepted as an autoimmune disease. This complex disease seems to implicate various cell types in both innate and adaptive compartments. Here, we discuss recent advances in the immunological field of MS research.

PMID:
25813101
DOI:
10.1016/j.lpm.2015.02.009
[Indexed for MEDLINE]

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