1. J Aging Res. 2015;2015:425261. doi: 10.1155/2015/425261. Epub 2015 Feb 19.

10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the
Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of
Rapamycin Signaling.

Honda Y(1), Araki Y(2), Hata T(2), Ichihara K(2), Ito M(3), Tanaka M(1), Honda
S(1).

Author information: 
(1)Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute 
of Gerontology, Sakaecho, Itabashiku, Tokyo 173-0015, Japan.
(2)Nagaragawa Research Center, Api Company Limited, Nagara, Gifu 502-0071, Japan.
(3)Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of
Gerontology, Sakaecho, Itabashiku, Tokyo 173-0015, Japan.

Royal jelly (RJ) produced by honeybees has been reported to possess diverse
health-beneficial properties and has been implicated to have a function in
longevity across diverse species as well as honeybees. 10-Hydroxy-2-decenoic acid
(10-HDA), the major lipid component of RJ produced by honeybees, was previously
shown to increase the lifespan of Caenorhabditis elegans. The objective of this
study is to elucidate signaling pathways that are involved in the lifespan
extension by 10-HDA. 10-HDA further extended the lifespan of the daf-2 mutants,
which exhibit long lifespan through reducing insulin-like signaling (ILS),
indicating that 10-HDA extended lifespan independently of ILS. On the other hand,
10-HDA did not extend the lifespan of the eat-2 mutants, which show long lifespan
through dietary restriction caused by a food-intake defect. This finding
indicates that 10-HDA extends lifespan through dietary restriction signaling. We 
further found that 10-HDA did not extend the lifespan of the long-lived mutants
in daf-15, which encodes Raptor, a target of rapamycin (TOR) components,
indicating that 10-HDA shared some longevity control mechanisms with TOR
signaling. Additionally, 10-HDA was found to confer tolerance against thermal and
oxidative stress. 10-HDA increases longevity not through ILS but through dietary 
restriction and TOR signaling in C. elegans.

DOI: 10.1155/2015/425261 
PMCID: PMC4350847
PMID: 25789174