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Colloids Surf B Biointerfaces. 2015 Apr 1;128:331-8. doi: 10.1016/j.colsurfb.2015.02.019. Epub 2015 Feb 17.

Sulfisoxazole/cyclodextrin inclusion complex incorporated in electrospun hydroxypropyl cellulose nanofibers as drug delivery system.

Author information

1
Institute of Materials Science & Nanotechnology, Bilkent University, Ankara 06800, Turkey; UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey.
2
UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey.
3
Institute of Materials Science & Nanotechnology, Bilkent University, Ankara 06800, Turkey; UNAM-National Nanotechnology Research Center, Bilkent University, Ankara 06800, Turkey. Electronic address: tamer@unam.bilkent.edu.tr.

Abstract

Herein, hydroxypropyl-beta-cyclodextrin (HPβCD) inclusion complex (IC) of a hydrophobic drug, sulfisoxazole (SFS) was incorporated in hydroxypropyl cellulose (HPC) nanofibers (HPC/SFS/HPβCD-IC-NF) via electrospinning. SFS/HPβCD-IC was characterized by DSC to investigate the formation of inclusion complex and the stoichiometry of the complex was determined by Job's plot. Modeling studies were also performed on SFS/HPβCD-IC using ab initio technique. SEM images depicted the defect free uniform fibers and confirmed the incorporation of SFS/HPβCD-IC in nanofibers did not alter the fiber morphology. XRD analyses showed amorphous distribution of SFS/HPβCD-IC in the fiber mat. Release studies were performed in phosphate buffered saline (PBS). The results suggest higher amount of SFS released from HPC/SFS/HPβCD-IC-NF when compared to free SFS containing HPC nanofibers (HPC/SFS-NF). This was attributed to the increased solubility of SFS by inclusion complexation. Sandwich configurations were prepared by placing HPC/SFS/HPβCD-IC-NF between electrospun PCL nanofibrous mat (PCL-HPC/SFS/HPβCD-IC-NF). Consequently, PCL-HPC/SFS/HPβCD-IC-NF exhibited slower release of SFS as compared with HPC/SFS/HPβCD-IC-NF. This study may provide more efficient future strategies for developing delivery systems of hydrophobic drugs.

KEYWORDS:

Cyclodextrin; Electrospinning; Hydroxypropyl cellulose; Molecular modeling; Nanofibers; Sulfisoxazole

PMID:
25769282
DOI:
10.1016/j.colsurfb.2015.02.019
[Indexed for MEDLINE]

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