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Expert Rev Proteomics. 2015 Apr;12(2):133-46. doi: 10.1586/14789450.2015.1024227. Epub 2015 Mar 9.

Spatial and temporal dynamics of the cardiac mitochondrial proteome.

Author information

1
Department of Physiology, The NHLBI Proteomics Center at UCLA, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA.

Abstract

Mitochondrial proteins alter in their composition and quantity drastically through time and space in correspondence to changing energy demands and cellular signaling events. The integrity and permutations of this dynamism are increasingly recognized to impact the functions of the cardiac proteome in health and disease. This article provides an overview on recent advances in defining the spatial and temporal dynamics of mitochondrial proteins in the heart. Proteomics techniques to characterize dynamics on a proteome scale are reviewed and the physiological consequences of altered mitochondrial protein dynamics are discussed. Lastly, we offer our perspectives on the unmet challenges in translating mitochondrial dynamics markers into the clinic.

KEYWORDS:

cardiovascular disease; mitochondria; protein dynamics; spatial dynamics; temporal dynamics

PMID:
25752359
PMCID:
PMC4721584
DOI:
10.1586/14789450.2015.1024227
[Indexed for MEDLINE]
Free PMC Article

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