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Pediatr Infect Dis J. 2015 Mar;34(3):326-8. doi: 10.1097/INF.0000000000000560.

Rotavirus vaccine virus shedding, viremia and clearance in infants with severe combined immune deficiency.

Author information

1
From the *National Reference Centre for Enteric Viruses, University Hospital of Dijon, Dijon, France; †Paediatric Immunology, Haematology and Rheumatology Unit, Necker Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, and Faculté Paris Descartes, Paris, France; ‡Laboratory of Virology, Necker Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

Abstract

We report for the first time Rotarix vaccine-acquired rotavirus infections with viremia in 2 infants vaccinated before being diagnosed with severe combined immune deficiency. Monitoring the first infant revealed that persistent rotavirus infection resolved after complete immune reconstitution was achieved by gene therapy.

PMID:
25742082
DOI:
10.1097/INF.0000000000000560
[Indexed for MEDLINE]

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