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Obes Surg. 2015 Nov;25(11):2071-7. doi: 10.1007/s11695-015-1644-4.

The Role of FTO and Vitamin D for the Weight Loss Effect of Roux-en-Y Gastric Bypass Surgery in Obese Patients.

Author information

1
Department Neuroscience, Functional Pharmacology, Uppsala University, Box 593, 751 24, Uppsala, Sweden. marcus.bandstein@neuro.uu.se.
2
Interdisciplinary Obesity Center, eSwiss Medical & Surgical Center, St. Gallen, Switzerland. bernd.schultes@stephanshorn.ch.
3
Interdisciplinary Obesity Center, eSwiss Medical & Surgical Center, St. Gallen, Switzerland. barbara.ernst@stephanshorn.ch.
4
Interdisciplinary Obesity Center, eSwiss Medical & Surgical Center, St. Gallen, Switzerland. martin.thurnheer@stephanshorn.ch.
5
Department Neuroscience, Functional Pharmacology, Uppsala University, Box 593, 751 24, Uppsala, Sweden. helgi.schioth@neuro.uu.se.
6
Department Neuroscience, Functional Pharmacology, Uppsala University, Box 593, 751 24, Uppsala, Sweden. christian.benedict@neuro.uu.se.

Abstract

BACKGROUND:

A recent study in children demonstrated that the rs9939609 single-nucleotide polymorphism in the fat mass and obesity (FTO) gene influences prospective weight gain, however, only in those who were vitamin D-deficient. If this might also be the case for Roux-en-Y gastric bypass (RYGB), surgery-induced weight loss is however unknown. The objective of this study is to examine if the magnitude of RYGB surgery-induced weight loss after 2 years depends on patients' FTO rs9939609 genotype (i.e., TT, AT, and AA) and presurgery vitamin D status (<50 nmol/L equals deficiency).

METHODS:

Before and at 24 months after RYGB surgery, BMI was measured in 210 obese patients (mean BMI 45 kg/m(2), 72 % females). Serum 25-hydroxyvitamin D3 levels were also repeatedly measured. Following surgery, vitamin D was supplemented. Possible weight loss differences between genotypes were tested with multiple linear regressions.

RESULTS:

The per-allele effect of each FTO A-allele on excessive BMI loss (EBMIL) was 3 % (P = 0.02). When split by baseline status, the EBMIL of vitamin D-deficient patients carrying AA exceeded that of vitamin D-deficient patients carrying TT by ~14 % (P = 0.03). No such genotypic differences were found in patients without presurgery vitamin D deficiency. Post-surgery serum levels of vitamin D did not differ between groups.

CONCLUSIONS:

Our data suggest that presurgery vitamin D levels influence the size of genotype effects of FTO rs9939609 on RYGB surgery-induced weight loss in obese patients.

KEYWORDS:

Bariatric surgery; FTO; RYGB; Vitamin D; Weight loss

PMID:
25724814
PMCID:
PMC4595530
DOI:
10.1007/s11695-015-1644-4
[Indexed for MEDLINE]
Free PMC Article

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