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Protein Cell. 2015 Mar;6(3):157-159. doi: 10.1007/s13238-015-0137-5.

CRISPR/Cas9 and TALE: beyond cut and paste.

Author information

1
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China.
2
Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 USA.
3
Beijing Institute for Brain Disorders, Beijing, 100069 China.
4
Center for Molecular and Translational Medicine, CMTM, Beijing, 100101 China.
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Contributed equally

Abstract

Nuclease-based genome editing has proven to be a powerful and promising tool for disease modeling and gene therapy. Recent advances in CRISPR/Cas and TALE indicate that they could also be used as a targeted regulator of gene expression, as well as being utilized for illuminating specific chromosomal structures or genomic regions.

PMID:
25722052
PMCID:
PMC4348244
DOI:
10.1007/s13238-015-0137-5
[Indexed for MEDLINE]
Free PMC Article

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